Research Overview

KPV

KPV (alpha-MSH C-terminal tripeptide)

A tripeptide fragment of alpha-MSH, studied for anti-inflammatory signaling independent of pigmentation effects.

What It Is

KPV (lysine-proline-valine) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Researchers use this minimal fragment specifically because it has been reported in the literature to retain alpha-MSH's anti-inflammatory signaling activity without the pigmentation-related effects associated with the full-length hormone, isolating one biological function for study.

As one of the smallest peptides studied in the inflammation literature, KPV is often used as a model compound for probing tripeptide-scale structure-activity relationships.

Mechanism in the Research Literature

Published research has examined KPV's effect on NF-kB signaling, a central transcription-factor pathway in inflammatory gene expression, with studies reporting inhibition of pro-inflammatory cytokine production in cell and tissue models. Research has also explored a PepT1-mediated uptake pathway in intestinal tissue, proposed as a route by which the tripeptide reaches relevant cell populations in gut-inflammation models.

Because of this literature base, KPV is frequently referenced in gastrointestinal and dermal inflammation research contexts as a tool for studying localized anti-inflammatory signaling.

Why Purity Verification Matters Here

At only three amino acids, KPV is chemically simple, but that simplicity raises its own quality-control question: a tripeptide is easier to synthesize incorrectly (wrong stereochemistry, incomplete coupling) without it being obvious on a basic assay. Mass spectrometry confirms exact molecular identity, and HPLC quantifies purity against synthesis byproducts, together ruling out the kind of subtle synthesis error that could otherwise be mistaken for a biological finding.

Third-party tested. Lot-matched. No exceptions.

Every unrl batch is characterized by independent third-party testing before it ships, not just an in-house spec sheet. Each Certificate of Analysis is tied to the lot number printed on the vial, so what you're holding matches a specific, published result rather than a generic average.

Independent lab, not manufacturer self-testing
HPLC purity + mass spectrometry identity confirmation
Lot-specific CoA, matched to the vial in hand
Published and searchable in the public COA library

View the COA Library

Research Use Only

This page is provided for research and educational purposes only. The compound discussed is a research reference standard, not a dietary supplement, drug, or article for human or veterinary use. Nothing on this page is medical advice, dosing guidance, or a claim of safety or efficacy. No statement has been evaluated by the FDA.

Quick Reference